Angiogenesis Induction
Vessel formation is crucial for bone remodeling process. In this study, we fabricated a selenium (Se) incorporated plasma electrolytic oxidation (PEO) coating on titanium (Ti) surface and its influence on the angiogenesis behaviors of human umbilical vein endothelial cells (HUVECs) were investigated. The Se-doped PEO coating exhibited a porous morphology and a sustained low does release of Se ions. Although the cells cultured on the coated Ti showed few differences in proliferation comparing to uncoated Ti, the cells exhibited a higher migration ratio and up-regulated angiogenesis-related genes (including KDR, VEGF, and HIF-α).
Therefore, the Se-doped PEO coating provides a new strategy to enhance vascularization surrounding the bone and thus facilitating bone regeneration after implantation.As a highly vascularized tissue, bone tissue needs blood vessels to maintain its integrity. Particularly, sufficient vascularization plays a vital role for bone repair, especially large bone defect repair. An active and mature blood vessel network guarantees the transportation of oxygen, nutrients, growth factors, and various cell types for bone rebuilding process. More importantly, evidence demonstrates that human umbilical vein endothelial cells (HUVECs) promote the secretion of osteogenic molecules in bone marrow stem cells (BMSCs) further highlighting the importance of angiogenic behaviors for bone regeneration. Therefore, fast angiogenic performance is crucial for bone repair implants.
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Regards
Mishita
Jornal co-ordinator
Journal of Heart and Cardiovascular Research