In the modern era, nanoparticles are the preferred dosage form, and maximum research is going on in the field of nanoparticle formulations. But as they are so small, nanoparticles are able to slip through the body's defenses and cause damage to the organs and tissues deep inside. In recent years, most researchers have focused solely on the therapeutic value of drugs or, at times, the performance of dosage forms, but few have given toxicity studies equal weight in their research. This review demonstrates that nanoparticle formulations are not suitable from a safety standpoint. So, researchers should be focused on alternative formulations like nanoemulsion, nanogel, and other liquids as well as semisolid formulations.

Magnetic nanoparticles, particularly ZnFe₂O₄ are of enormous significance in biomedical and water treatment fields. However, chemical synthesis of ZnFe₂O₄ nanoparticles endures some major limitations, e.g., the use of toxic substances, unsafe procedure, and cost-ineffectiveness. Biological methods are more preferable approaches since they take advantages of biomolecules available in plant extract serving as reducing, capping, and stabilizing agents. Herein, we review plant-mediated synthesis and properties of ZnFe₂O₄ nanoparticles for multiple applications in catalytic and adsorption performance, biomedical, catalyst, and others. Effect of several factors such as Zn²⁺/Fe³⁺/extract ratio, and calcination temperature on morphology, surface chemistry, particle size, magnetism and bandgap energy of obtained ZnFe₂O₄ nanoparticles was discussed. The photocatalytic activity and adsorption for removal of toxic dyes, antibiotics, and pesticides were also evaluated. Main results of antibacterial, antifungal and anticancer activities for biomedical applications were summarized and compared. Several limitations and prospects of green ZnFe₂O₄ as an alternative to traditional luminescent powders have been proposed.

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Jenny
Journal Co-ordinator
Journal of Nano Research & Applications