Description:

Chronic Renal Failure (CRF) refers to progressive renal damage caused by Chronic Kidney Diseases (CKD). Dialysis therapy and kidney transplantation are the important treatment for CRF. However, due to the limitation of conditions, they cannot be widely utilized. At present, the treatment of renal failure is a worldwide problem in clinic. Therefore, in the current study, we investigated the potential therapeutic effects of neoxanthin on CFR-caused aging and fibrosis. In this work, the effects of neoxanthin on CRF were studied using experimental techniques such as biochemistry, immunohistochemistry and molecular biology. In vitro, neoxanthin alleviated the aging and oxidative damage of kidney cells. In vivo, we found that Neoxanthin could alleviate adenine-induced CRF. Neoxanthin also inhibited CRF-caused renal aging, fibrosis, oxidative stress and inflammation. These findings indicate that neoxanthin could delay the progression of CRF and alleviate CRF-induced aging and fibrosis. Collectively, we found that neoxanthin shows good potential to inhibit CRF-caused kidney aging and fibrosis, suggesting that neoxanthin may be used as a drug (or a functional food) for the treatment of CRF-related diseases. Hepatitis A is the most prevalent viral hepatitis in India and rarely can lead to life-threatening complications such as acute liver failure (ALF). Glucose 6 phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world, and in the setting of acute viral hepatitis, it can cause massive intravascular hemolysis, resulting in acute kidney injury. Here, we report a case of a 12-year-old male child who had hepatitis A–associated ALF, which was complicated by massive hemolysis due to underlying G6PD deficiency, manifesting as acute renal failure requiring renal replacement therapy with other supportive management. He had a prolonged, protracted stormy clinical course, which was further complicated by dialysis disequilibrium syndrome, posterior reversible encephalopathy syndrome, and nosocomial sepsis, which improved over 4 weeks. Our case highlights the importance of having high index of clinical suspicion for G6PD deficiency in a child with acute viral hepatitis with complications. In this report we describe the clinical journey of a 62-year-old male that presented with acute kidney injury secondary to Erdheim-Chester disease, a non-Langerhans variant of histiocytosis rarely encountered by urological surgeons. ECD can uncommonly cause acute renal failure and management includes decompression of the collecting system. A multi-disciplinary approach is required to facilitate adequate investigation to determine the specific ECD subtype and most appropriate treatment options, particularly as the available targeted therapies have only recently been utilised.

In this study, 60 samples taken from patients with thyroid dysfunction, 40 samples taken from patients with chronic renal failure (CRF) and 60 samples taken from healthy people were classified. We used partial least squares (PLS) to extract features to reduce the dimension of the spectral data to discriminate among the different samples. The Decision Trees (DT), Extreme Learning Machine (ELM), Probabilistic Neural Network (PNN), Back Propagation Neural Network (BPNN) and Learning Vector Quantization (LVQ) algorithms were used to build classification models and compare the results. The PLS-PNN algorithm distinguished between patients with thyroid dysfunction and patients with chronic renal failure with up to a 96.67 % accuracy rate, the PLS-BP algorithm distinguished between patients with chronic renal failure and healthy people with up to a 98.33 % accuracy rate, and the PLS-PNN algorithm and the PLS-DT algorithm distinguished between healthy people and patients with chronic renal failure with up to a 100 % accuracy rate. The results showed that serum Raman spectroscopy can be used in conjunction with classification algorithms to rapidly and accurately diagnose and distinguish between thyroid dysfunction and chronic renal failure.

With Regards
 Valider
Journal Coordinator
Global Journal of Research and Review