Description

Immunology has come a long way, from its early religious beginnings thousands of years ago, to the explosion of immunological data in the 21st century. Thanks to discoveries in immunology, our world has seen tremendous progress in how we understand and treat disease. However, a lot of unmet clinical needs remain, which require focused, real-time collaboration at the clinical and scientific research forefronts. Moreover, the current exponential growth in the generation of research data makes it impossible to handle, analyse, visualize, and interpret such data without the use of advanced computational tools. We think immunoinformatics- a discipline at the intersection of immunology and computer science- will greatly increase efficiency in research productivity and disease treatment. This perspective paper aims to emphasize the role of immunoinformatics toward pushing the boundaries of immunology research. It will also illustrate its clinical applications, including disease prevention, diagnosis, prognosis, treatment, monitoring, as well as in drug discovery. We believe informatics approaches will be implemented increasingly more frequently in research. Thus, here we also discuss a set of fundamental prerequisites to facilitate the efficient and ethical integration of informatics in research and ensure immunological advancements provide maximum benefits to society.

In the past, tumor and microbial infection were commonly regarded as independent diseases with few interrelations. The discovery of bacteria in tumor tissue changed the knowledge of bacteria-tumor relationship. Recently, more and more findings have demonstrated the significant effects of bacteria on the genesis, development and metastasis of tumor. Particularly, the influence of bacteria on tumor immunity is of great interest. Bacteria can inhibit the function of immune system through multiple mechanisms. On the other hand, some bacteria can also enhance the immune response and inhibit tumor progression. Understanding the bacteria-tumor interactions is of great importance for developing novel anticancer approaches. Herein, we aim to provide a comprehensive understanding of the tumor/tumor immunology, the biogenesis of bacteria in tumor and the relation of tumorigenesis with bacteria. In addition, the roles of bacteria in tumor immunology and the potential approaches to use bacteria for cancer therapy are discussed. Immunology has come a long way, from its early religious beginnings thousands of years ago, to the explosion of immunological data in the 21st century. Thanks to discoveries in immunology, our world has seen tremendous progress in how we understand and treat disease. However, a lot of unmet clinical needs remain, which require focused, real-time collaboration at the clinical and scientific research forefronts. Moreover, the current exponential growth in the generation of research data makes it impossible to handle, analyse, visualize, and interpret such data without the use of advanced computational tools. We think immunoinformatics- a discipline at the intersection of immunology and computer science- will greatly increase efficiency in research productivity and disease treatment.

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With Regards

Amelia
Journal Coordinator
Global Journal of Research and Review