Clinical Immunology and Allergy : A Modern Era in Approaching Cystic Fibrosis

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Journal of Clinical Immunology and Allergy is a world class open access journal intended to publish the cutting-edge research in the field of Immunology and Allergy.

Journal of Clinical Immunology and Allergy has developed very significantly as a speciality over the past years, and has the understanding of the immunological basis of many diseases and the development of immunological therapies.

Cystic fibrosis (CF) is an autosomal recessive genetic disorder characterized by multi-system manifestations and limited life expectancy. Although it is a multi-system disease its main manifestation is expressed as a progressive chronic lung disease which at the present time accounts for the vast majority of morbidity and mortality.

The CF lung disease is chronic and progressive represented by bronchiectasis, recurrent pulmonary infections with tenacious secretions, mucus plugging and gradual decline in lung function. The essence of Cystic Fibrosis is a dysfunctional Cystic Fibrosis Trans membrane Conductance Regulator (CFTR) protein which is deficient or defective. Median life expectancy before 1950 was less than five years, but with the introduction of pancreatic enzymes median life expectancy rose to 10 years by 1960.

As anti-staphylococcal antimicrobials were introduced into the care of CF median life expectancy by 1970 was approximately 15 years. their important regimens included more effective airway clearance devises, inhaled Pulmozyme (DNase), hypertonic saline, anti-inflammatory agents and the ultimate intervention with lung transplantation for end-stage lung disease.

A new era in treating CF has emerged in recent years and its noticeable success has been characterized as "the end of the beginning"

An approach similar to that used in severe eosinophilic asthma with frequent exacerbations can certainly be adapted to the CF population where by the common important denominator is inflammation.

Allergic diseases include hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. An allergy is an unnecessary immune response to an innocuous substance. The most common way to diagnose an IgE-mediated allergy is through a blood test to identify allergen specific IgE or a skin prick test which results in a local inflammatory reaction after administration of the trigger allergen.

To provide with the more detailed information the journal accepts original manuscripts in the form of Research Articles, Review Articles, Clinical Reviews, Commentaries, Case Reports, Perspectives and Short Communications encompassing all aspects of Clinical Immunology and Allergy for publication in open access platform.

All the manuscript published by Clinical Immunology and Allergy are available freely online immediately after publication without any subscription charges or registration.

Manuscripts can be submitted at:http://www.imedpub.com/submissions/insights-allergy-asthma-bronchitis.html

or can be submitted as an attachment to this E-mail: clinicalimmuno@clinicalmedicaljournals.com

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Media Contact
Sana George
Journal Manager
Clinical Immunology and Allergy
Email: clinicalimmuno@clinicalmedicaljournals.com
WhatsApp: +1-947-333-4405