Description

Fallopian tube torsion is a rare finding in women presenting with abdominal pain, and it is exceedingly rare for it to be associated with concomitant appendicitis. The clinical presentation of isolated fallopian tube torsion can be a diagnostic problem because there are no specific clinical features. Early consideration of the diagnosis and prompt surgical management are required, as this can help to preserve the fallopian tube. Ovarian and fallopian tube indirect inguinal hernias are rare hernias encountered on surgical floor. Herein, we are reporting a rare happening of obstructed ovarian and fallopian tube indirect inguinal hernia in an unmarried female.

High grade serous ovarian cancers (HGSOC) predominantly arise in the fallopian tube epithelium (FTE) and colonize the ovary first, before further metastasis to the peritoneum. Ovarian cancer risk is directly related to the number of ovulations, suggesting that the ovary may secrete specific factors that act as chemo attractants for fallopian tube derived tumor cells during ovulation. We found that 3D ovarian organ culture produced a secreted factor that enhanced the migration of FTE non-tumorigenic cells as well as cells harboring specific pathway modifications commonly found in high grade serous cancers. Through size fractionation and a small molecule inhibitors screen, the secreted protein was determined to be 50–100kDa in size and acted through the Epidermal Growth Factor Receptor (EGFR). To correlate the candidates with ovulation, the PREDICT organ-on-chip system was optimized to support ovulation in a perfused microfluidic platform. Versican was found in the correct molecular weight range, contained EGF-like domains, and correlated with ovulation in the PREDICT system. Exogenous versican increased migration, invasion, and enhanced adhesion of both murine and human FTE cells to the ovary in an EGFR-dependent manner. The identification of a protein secreted during ovulation that impacts the ability of FTE cells to colonize the ovary provides new insights into the development of strategies for limiting primary ovarian metastasis. Lymphangiomas are benign tumors that results from congenital malformation of lymphatic vessels. They are generally found in the neck and axilla. When they involve multiple locations, they present as lymphangiomatosis syndrome. Generalized lymphangiomatosis associated with mucinous cystadenoma of the ovary is a very rare condition. This study describes a 13-year-old girl with lymphangiomatosis of spleen, right fallopian tube and abdominal wall associated with mucinous cystadenoma of the right ovary. Contrast-enhanced abdominopelvic computed tomography scan and magnetic resonance image showed a multiple cystic splenic mass and huge abdominopelvic cystic mass. Splenectomy, excision of right ovary and fallopian tube mass, and excision of abdominal wall mass were performed without any complications.

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With Regards
Jessie

Journal Coordinator
Journal of Reproductive Endocrinology & Infertility