Global concerns about reducing or minimizing the costs associated with toxic waste materials have driven the continuing development of green-cell-based biosynthesis methods. Inspired by the hybridization phenomenon of living organisms, recent interest has arisen in nanocell hybrids that possess multiple new functions. They have potential to propel biosynthesis into a new generation of green chemistry. This review article discusses the development of applications for nanocell hybrids in the areas of sustainable energy, clean environment, and green catalysis. Continuing advances in these hybrids will require combining knowledge from the fields of biology, physics, chemistry, material science, and engineering.

Immunotherapy has emerged as a powerful new chapter in the fight against cancer. However, it has yet to reach its full potential due in part to the complexity of the cancer immune response. We demonstrate that tumor-targeting EDV nanocells function as an immunotherapeutic by delivering a cytotoxin in conjunction with activation of the immune system. These nanocells polarize M1 macrophages and activate NK cells concurrently producing a Th1 cytokine response resulting in potent antitumor function. Dendritic cell maturation and antigen presentation follows, which generates tumor-specific CD8⁺ T cells, conferring prolonged tumor remission. The combination of cytotoxin delivery and activation of innate and adaptive antitumor immune responses results in a potent cyto-immunotherapeutic with potential in clinical oncology.

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Jenny
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Journal of Nano Research & Applications