Stem cells from human exfoliated deciduous teeth (SHED) play a significant role in tissue engineering and regenerative medicine. Angiogenesis is crucial in tissue regeneration and a primary target of regenerative medicine. As a first-line anti-diabetic drug, metformin demonstrates numerous valuable impacts on stem cells. This study aimed to explore metformin's impact and mechanism of action on SHED-mediated angiogenesis.Stem cell-based therapy is considered a novel option for the treatment of diseases. Mesenchymal stem cells (MSCs) are pluripotent stem cells that exhibit low immunogenicity and have multi-directional differentiation potential. They can be obtained from different tissues, including umbilical cord blood, bone marrow, adipose tissue and dental pulp. Dental pulp-derived stem cells, including stem cells from human exfoliated deciduous teeth (SHED), have the characteristics of self-renewal that belong to ecto-MSCs, which is an ideal source of stem cells. SHED is obtained from the pulp of naturally replaced deciduous teeth.

It causes insignificant damage to donors, has no restrictions based on moral or ethical issues and demonstrates a low risk of tumorigenesis after transplantation. In addition, it has potential clinical value because of its relative lack of immunogenicity. Under the condition of directional differentiation, SHED has the capacity to differentiate into osteocytes, hepatocytes, muscle cells, nerve cells and skin cells in vitro and in vivo. It has significant benefits and demonstrates satisfactory application prospects in stem cell-based therapy. Therefore, cell therapy using dental pulp-derived stem cells is a promising treatment and has evolved as a research hot spot in regenerative medicine.

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Mishita
Jornal co-ordinator
Journal of Heart and Cardiovascular Research