Mineral and bone metabolism disrorder in the context of chronic kidney disease (CKD-MBD) constitutes a major complication defined as abnormalities in serum calcium, phosphorus, parathyroid hormone (PTH), and vitamin D, in association with vascular calcification and bone anomalies. CKD-MBD contributes to the high mortality rate among patients on dialysis. Calcium and phosphate metabolism disorders are common in patients on dialysis and have been associated with myocardial hypertrophy, vascular calcification, arterial dysfunction and increased morbidity and mortality . A positive calcium load has a huge negative impact on vascular calcification for both PD and hemodialysis patients. Therefore, maintaining neutral calcium and phosphate balance and suitable PTH levels has become the focus of attention.

Peritoneal dialysis-associated peritonitis (PDAP) is the most common complication in peritoneal dialysis patients. We propose screening for characteristic expressed proteins in the dialysate of PDAP patients to provide clues for the diagnosis of PDAP and its therapeutic targets.Dialysis allows children with chronic kidney disease a means of support until renal transplant is feasible. All forms of renal replacement therapy require a surgical intervention, whether the modality is hemodialysis or peritoneal dialysis. Despite peritoneal dialysis being the most common modality of dialysis in children, there is not prospectively collected much evidence in the literature which can guide the pediatric surgeon about best practices on access placement, management of complications, and timing of removal. Most available studies are small, single-center retrospective reviews. This limits the power of the data collected to help guide decision-making in the management of peritoneal dialysis catheters.

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Mishita
Jornal co-ordinator
Journal of Clinical & Experimental Nephrology