New types of surface functionalized silver-cinnamon nanoshells (Ag-CNSs) were produced in deionized water using PLAL method and characterized. Anticancer effectiveness and cytotoxicity of these Ag-CNSs against liver hepatocellular carcinoma cancer (HepG2) and normal (WRL68) cell lines was evaluated. XRD and EDX analyses of Ag-CNSs showed their excellent crystallinity and elemental compositions. HRTEM micrographs displayed the existence of cinnamon protein-capped spherical Ag nanocrystallites of size 11.12 ± 1.32 nm. These ultra-sensitive Ag-CNSs with wide surface area revealed an improved fluorescence and surface plasmon resonance (SPR) absorption. The achieved Ag-CNSs exhibited strong anticancer activity (high cytotoxicity, log IC50 ≈ 59.1%), indicating the feasibility of developing novel drugs for cancer cure. It was shown that via the surface functionalization, the anticancer efficacy of the proposed Ag-CNSs can be tailored.

The novelty of the current work is that the nonlocal parameters vary smoothly through the thickness of the nanoshells which is never investigated in the past. Four types of the doubly curved nanoshells named flat plates, spherical shells, hyperbolic parabolic shells, and cylindrical shells are considered. The first-order shear deformation theory, the nonlocal elasticity theory, and Hamilton’s principle are used to establish the governing equations of motion of the functionally graded doubly curved nanoshells. The frequencies of the simply supported functionally graded doubly curved nanoshells are carried out via Navier’s solution technique. The numerical results obtained by the proposed formulations are compared with other published results in several special cases to demonstrate the accuracy and efficiency of the developed model. Furthermore, the effects of some parameters such as the nonlocal parameters, the power-law index, the thickness-to-sides ratio, the radius ratio on the free vibration response of the functionally graded doubly curved nanoshells are investigated in detail.

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Jenny
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Journal of Nano Research & Applications