Angiogenesis is a biological process in which resting endothelial cells start proliferating, migrating and forming new blood vessels. Angiogenesis is particularly important in the repair of bone tissue defects. Naringin (NG) is the main active monomeric component of traditional Chinese medicine, which has various biological activities, such as anti-osteoporosis, anti-inflammatory, blood activation and microcirculation improvement. At present, the mechanism of naringin in the process of angiogenesis is not clear. PIWI protein-interacting RNA (piRNA) is a small noncoding RNA (sncRNA) that has the functions of regulating protein synthesis, regulating the structure of chromatin and the genome, stabilizing mRNA and others. Several studies have demonstrated that piRNAs can mediate the angiogenesis process. Whether naringin can interfere with the process of angiogenesis by regulating piRNAs and related target genes deserves further exploration.

Thus, the purpose of this study was to validate the potential angiogenic and bone regeneration properties and related mechanisms of naringin both in vivo and in vitro.Angiogenesis is defined as the development of new blood capillaries from preexisting capillaries or postcapillary veins and is a complex dynamic process involving multiple cells, matrix, and cytokines. This procedure includes the following: (I) vascular endothelial cells are activated and begin to degrade the peripheral matrix; (II) endothelial cells migrate into the mesenchyme; (III) capillary buds and sprouts form; and (IV) capillary buds proliferate. Angiogenesis has been one of the determining factors in the regeneration of different tissues and organs. It is an important process in wound healing because the newly formed vessels contribute to the formation of granulation tissue and provide oxygen and nutrients to the injured area.

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Mishita
Jornal co-ordinator
Journal of Heart and Cardiovascular Research