Study on Responses Of C-peptide And Blood Glucose For Carbohydrate 70g in Diabetes

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Study on Responses Of C-peptide And Blood Glucose For Carbohydrate 70g in Diabetes

Abstract

Background: Discussion concerning Carbohydrate Restriction (CR) and Low Carbohydrate Diet (LCD) has been continued. Authors formerly proposed insulinogenic index-carbohydrate 70 g (IGI-carbo70). Along this, C-peptide index for Carbohydrate-70 g (CPI-Carbo70) is studied.

Subjects and Methods: Subjects were 46 patients (62.5 yo. in average) with Type 2 diabetes mellitus (T2DM) and admitted for evaluation. CR diet was given on day 1-2 with 60% carbohydrates, 25% lipids and 15% protein with 1400 kcal/day. On day 2, breakfast with Carbo70 was given, and glucose and C-peptide (CP) were measured at 0 and 30 minutes and analyzed.

Results: As basal data, average HbA1c was 8.1%, median HbA1c, average daily glucose, median M value was 7.7%, 187 mg/dL, 71, respectively. In response to Carbo70, median values of glucose-0, glucose-30, delta-glucose, CP-0, CP-30, delta-CP was 142, 186, 22 mg/dL, 0.9, 1.4, 0.4 ng/mL, respectively. CPI-Carbo70 was 1.54 in median. There were significant correlation between glucose and-CP on 0, 30min, delta-0-30min (p<0.01). Significant correlation was observed between CPI and HbA1c, CPI and M value (p<0.01).

Discussion and Conclusion: CPI-Carbo70 might be useful for evaluating pancreas function and glucose variability in clinical research. Current data would become the fundamental data for the future diabetic practice and research development.

Full Article: https://www.imedpub.com/articles/study-on-responses-of-cpeptide-and-blood-glucose-for-carbohydrate-70g-indiabetes.php?aid=23138

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