Description:

In recent years, studies have reported the role of stress-regulatory hormones, including epinephrine, in regulating the progression of a few cancers. However, the tumor-promoting action of epinephrine is not yet investigated in T cell malignancy, a rare and complicated neoplastic disorder. More so, very little is known regarding the implication of epinephrine in the glucose metabolic rewiring in tumor cells. The present investigation showed that epinephrine enhanced the proliferation of T lymphoma cells through up- and down-regulating the expression of PCNA, cyclin D, and p53, respectively. In addition, epinephrine inhibited apoptosis in T lymphoma cells possibly by increasing the level of BCL2 (an anti-apoptotic protein) and decreasing PARP level (a pro-apoptotic protein). Intriguingly, epinephrine is reported to stimulate glycolysis in T lymphoma cells by increasing the expression of crucial glycolysis regulatory molecules, namely HKII and PKM2, in a HIF-1α-dependent manner. Moreover, augmented production of ROS has been observed in T lymphoma cells, which might be a central player in epinephrine-mediated T cell lymphoma growth. Taken together, our study demonstrates that epinephrine might have a significant role in the progression of T cell lymphoma.

A facile sensing platform was established for the electrochemical detection of epinephrine using titanium dioxide-reduced graphene oxide nanofibers (TiO2-rGO NFs) nanocomposite modified glassy carbon electrode. The TiO2-rGO NFs were prepared using electrospinning followed by hydrothermal method, characterized by various state-of-the-art techniques, and the fabricated sensor were characterized by cyclic voltammetry and differential pulse voltammetry. Using the optimal experimental conditions potential scan rate, linear correlation between analytical signal and concentration of 10–100 nM with a detection limit of 8.11 nM, and sensitivity 0.126 µA µM−1 were observed. The constructed sensor were evaluated the sensing of epinephrine in human serum and drug injection samples. The developed electrochemical sensor provides a potential candidate for the accurate sensing of epinephrine in biological fluids and pharmaceutical drugs.

Epinephrine hormone as neurotransmitter is a crucial component for the efficient working of the human cardio-respiratory and central nervous or peripheral nervous systems. Efficient quantification of the epinephrine level in biological fluids is critical in diagnosing several significant diseases. The present research problem focused on the synthesized the multiwall carbon nanotubes (MW-CNTs) functionalized with MoS2 heterostructure using the hydrothermal route and further explored its applicability to detect neurotransmitter i.e. epinephrine. The morphological and structural characterization of the MoS2-MW/CNTs heterostructure was examined by employing morphological as well as spectroscopic techniques. Results showed that heterostructures were well decorated with 2-dimensional MoS2 nano-flakes, which enhance material electro-catalytic activity for better electrochemical communication.

With Regards
Anissa
Journal Coordinator
Global Journal of Research and Review